dafeeeeeeeeeesh Facepalm
The Mak can harvest your matter faster than a machine gun can fire. The Mak can also harvest it from long range.
They can literally manipulate matter at will, which is how they can churn out drones faster than Flash can ever run. They'll simply harvest your bomb for resources then make more of themselves.
Cannon fire can also be intercepted.
Self Destruct? Ooh, the Mak will just eat the remains of your structures to create more Mak.
The only types of weapons that can hurt the Mak a lot are thermal weaponry. Sure, your antimatter vaporization will work at first, but even if the antimatter shell gets through the millions of matter-eating drones, the Mak will simply make up with billions more drones and adapt.
EDIT: Oh, did i mention that the Mak have eaten entire galaxies, and even a really OP galaxy was eaten in five years?
(eat isn't an accurate term though.)